Evaluation of edaravone against radiation-induced oral mucositis in mice
نویسندگان
چکیده
منابع مشابه
Radiation-Induced Oral Mucositis
Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has marked adverse effects on patient quality of life and cancer therapy continuity. It is a challenge for radiation oncologists since it leads to cancer therapy interruption, poor local tumor control, and changes i...
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OBJECTIVES This study aims to investigate whether propolis has a protective role in oral mucosal damage induced by radiotherapy applied to head-neck region, using quantitative, biochemical and histopathological approaches. MATERIALS AND METHODS Forty eight Wistar-Albino adult female rats at eight weeks of age and weighing 213±27 grams were included in this study and randomly divided into six ...
متن کاملEvaluation of radiation-induced oral mucositis by optical coherence tomography.
PURPOSE Optical coherence tomography (OCT) imaging was evaluated to determine if radiation-induced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings. EXPERIMENTAL DESIGN Female C3H mice, ages 7 to 9 weeks, four per group, were immobilized in a custom-made Lucite jig and received 0, 15, 22.5, and 25 Gy in a single fraction to their oral c...
متن کاملRadiation therapy and chemotherapy-induced oral mucositis.
UNLABELLED Increasing the intensity of radiation therapy and chemotherapy in the management of cancer has increased the incidence of adverse effects, especially oral mucositis. AIM AND METHODS a bibliographical review was conducted on the definition of oral mucositis, its clinical findings, the incidence, its etiology, the pathophysiology, associated morbidity, prevention and treatment. RES...
متن کاملEffect of Epicatechin against Radiation-Induced Oral Mucositis: In Vitro and In Vivo Study
PURPOSE Radiation-induced oral mucositis limits the delivery of high-dose radiation to head and neck cancer. This study investigated the effectiveness of epicatechin (EC), a component of green tea extracts, on radiation-induced oral mucositis in vitro and in vivo. EXPERIMENTAL DESIGN The effect of EC on radiation-induced cytotoxicity was analyzed in the human keratinocyte line HaCaT. Radiatio...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2015
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2015.02.001